Publications
The UMGC develops novel genomic approaches through our own research & development in our Innovation Lab and also in collaboration with clients. Papers listed below in black font are publications on which UMGC staff are co-authors with the UMGC staff in bold. Publication titles in blue font are UMGC-initiated work for which UMGC scientists are the PIs and lead authors.
The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research.
McCartney MA, Auch B, Kono T, Mallez S, Zhang Y, Obille A, Becker A, Abrahante JE, Garbe J, Badalamenti JP, Herman A, Mangelson H, Liachko I, Sullivan S, Sone ED, Koren S, Silverstein KAT, Beckman KB, Gohl DM.
bioRxiv 696732. 2019 July 9.
Measuring sequencer size bias using REcount: a novel method for highly accurate Illumina sequencing-based quantification.
Gohl DM, Magli A, Garbe J, Becker A, Johnson DM, Anderson S, Auch B, Billstein B, Froehling E, McDevitt SL, Beckman KB. Measuring sequencer size bias using REcount: a novel method for highly accurate Illumina sequencing-based quantification.
Genome Biol. 2019 Apr 29;20(1):85.
Loci for human leukocyte telomere length in the Singaporean Chinese population and transethnic genetic studies.
Dorajoo R, Chang X, Gurung RL, Li Z, Wang L, Wang R, Beckman KB, Adams-Haduch J, M Y, Liu S, Meah WY, Sim KS, Lim SC, Friedlander Y, Liu J, van Dam RM, Yuan JM, Koh WP, Khor CC, Heng CK.
Nat Commun. 2019 Jun 6;10(1):2491.
Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory.
Hartman P, Beckman K, Silverstein K, Yohe S, Schomaker M, Henzler C, Onsongo G, Lam HC, Munro S, Daniel J, Billstein B, Deshpande A, Hauge A, Mroz P, Lee W, Holle J, Wiens K, Karnuth K, Kemmer T, Leary M, Michel S, Pohlman L, Thayanithy V, Nelson A, Bower M, Thyagarajan B.
Mol Genet Metab Rep. 2019 Mar 1;19:100464.
Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways.
Minato Y, Gohl DM, Thiede JM, Chacón JM, Harcombe WR, Maruyama F, Baughn AD.
mSystems. 2019 Jun 25;4(4). pii: e00070-19.
Resequencing Study Confirms Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.
Moore C et al (including Beckman KB).
Am J Respir Crit Care Med. 2019 Apr 29.
Evaluating the Information Content of Shallow Shotgun Metagenomics.
Hillmann B, Al-Ghalith GA, Shields-Cutler RR, Zhu Q, Gohl DM, Beckman KB, Knight R, Knights D.
mSystems. 2018 Nov 13;3(6). pii: e00069-18.
Comprehensive Functional Analysis of the Enterococcus faecalis Core Genome Using an Ordered, Sequence-Defined Collection of Insertional Mutations in Strain OG1RF.
Dale JL, Beckman KB, Willett JLE, Nilson JL, Palani NP, Baller JA, Hauge A, Gohl DM, Erickson R, Manias DA, Sadowsky MJ, Dunny GM.
mSystems. 2018 Sep 11;3(5). pii: e00062-18.
Optimization of a microfluidics-based next generation sequencing assay for clinical oncology diagnostics.
Henzler C, Schomaker M, Yang R, Lambert AP, LaRue R, Kincaid R, Beckman K, Kemmer T, Wilson J, Yohe S, Thyagarajan B, Nelson AC.
Ann Transl Med. 2018 May;6(9):162.
Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study.
Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, Fenech M, Koh WP.
Int J Cancer. 2018 Jun 1;142(11):2234-2243.
EditR: A Method to Quantify Base Editing from Sanger Sequencing.
Kluesner MG, Nedveck DA, Lahr WS, Garbe JR, Abrahante JE, Webber BR, Moriarity BS.
CRISPR J. 2018 Jun;1:239-250.
The ecological landscape of microbiome science.
Gohl DM.
Nat Biotechnol. 2017 Nov;35(11):1047-1049.
Single-Strand Consensus Sequencing Reveals that HIV Type but not Subtype Significantly Impacts Viral Mutation Frequencies and Spectra.
Rawson JMO, Gohl DM, Landman SR, Roth ME, Meissner ME, Peterson TS, Hodges JS, Beckman KB, Mansky LM.
J Mol Biol. 2017 Jul 21;429(15):2290-2307.
Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells.
Winterhoff BJ, Maile M, Mitra AK, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK.
Gynecol Oncol. 2017 Mar;144(3):598-606.
Preferential suppression of Anopheles gambiae host sequences allows detection of the mosquito eukaryotic microbiome.
Belda E, Coulibaly B, Fofana A, Beavogui AH, Traore SF, Gohl DM, Vernick KD, Riehle MM.
Sci Rep. 2017 Jun 12;7(1):3241.
Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies.
Gohl DM, Vangay P, Garbe J, MacLean A, Hauge A, Becker A, Gould TJ, Clayton JB, Johnson TJ, Hunter R, Knights D, Beckman KB.
Nat Biotechnol. 2016 Sep;34(9):942-9.
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.
Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA.
BMC Genet. 2016 Jun 7;17(1):74.
No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort.
Giorgi EE, Li Y, Caberto CP, Beckman KB, Lum-Jones A, Haiman CA, Le Marchand L, Stram DO, Saxena R, Cheng I.
Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):1001-3.
Toward clinical genomics in everyday medicine: perspectives and recommendations.
Delaney SK, Hultner ML, Jacob HJ, Ledbetter DH, McCarthy JJ, Ball M, Beckman KB, Belmont JW, Bloss CS, Christman MF, Cosgrove A, Damiani SA, Danis T, Delledonne M, Dougherty MJ, Dudley JT, Faucett WA, Friedman JR, Haase DH, Hays TS, Heilsberg S, Huber J, Kaminsky L, Ledbetter N, Lee WH, Levin E, Libiger O, Linderman M, Love RL, Magnus DC, Martland A, McClure SL, Megill SE, Messier H, Nussbaum RL, Palaniappan L, Patay BA, Popovich BW, Quackenbush J, Savant MJ, Su MM, Terry SF, Tucker S, Wong WT, Green RC.
Expert Rev Mol Diagn. 2016;16(5):521-32.
Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery.
Baldwin EA, Walther-Antonio M, MacLean AM, Gohl DM, Beckman KB, Chen J, White B, Creedon DJ, Chia N.
PeerJ. 2015 Nov 26;3:e1398.
Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.
Li Y, Beckman KB, Caberto C, Kazma R, Lum-Jones A, Haiman CA, Le Marchand L, Stram DO, Saxena R, Cheng I.
PLoS One. 2015 Sep 4;10(9):e0136796.
mRNA 3‘-UTR shortening is a molecular signature of mTORC1 activation.
Chang JW, Zhang W, Yeh HS, de Jong EP, Jun S, Kim KH, Bae SS, Beckman K, Hwang TH, Kim KS, Kim DH, Griffin TJ, Kuang R, Yong J.
Nat Commun. 2015 Jun 15;6:7218.
Next generation sequencing in endocrine practice.
Forlenza GP, Calhoun A, Beckman KB, Halvorsen T, Hamdoun E, Zierhut H, Sarafoglou K, Polgreen LE, Miller BS, Nathan B, Petryk A.
Mol Genet Metab. 2015 Jun-Jul;115(2-3):61-71.
Clinical validation of targeted next-generation sequencing for inherited disorders.
Yohe S, Hauge A, Bunjer K, Kemmer T, Bower M, Schomaker M, Onsongo G, Wilson J, Erdmann J, Zhou Y, Deshpande A, Spears MD, Beckman K, Silverstein KA, Thyagarajan B.
Arch Pathol Lab Med. 2015 Feb;139(2):204-10.
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.
Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, Tsung K, John EM, Torres-Mejia G, Carvajal-Carmona L, Echeverry MM, Tuazon AM, Ramirez C; COLUMBUS Consortium, Gignoux CR, Eng C, Gonzalez-Burchard E, Henderson B, Le Marchand L, Kooperberg C, Hou L, Agalliu I, Kraft P, Lindström S, Perez-Stable EJ, Haiman CA, Ziv E.
Nat Commun. 2014 Oct 20;5:5260.
Implementation of Cloud based next generation sequencing data analysis in a clinical laboratory.
Onsongo G, Erdmann J, Spears MD, Chilton J, Beckman KB, Hauge A, Yohe S, Schomaker M, Bower M, Silverstein KA, Thyagarajan B.
BMC Res Notes. 2014 May 23;7:314.
Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.
Battle A, Mostafavi S, Zhu X, Potash JB, Weissman MM, McCormick C, Haudenschild CD, Beckman KB, Shi J, Mei R, Urban AE, Montgomery SB, Levinson DF, Koller D.
Genome Res. 2014 Jan;24(1):14-24.
Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.
Mostafavi S, Battle A, Zhu X, Potash JB, Weissman MM, Shi J, Beckman K, Haudenschild C, McCormick C, Mei R, Gameroff MJ, Gindes H, Adams P, Goes FS, Mondimore FM, MacKinnon DF, Notes L, Schweizer B, Furman D, Montgomery SB, Urban AE, Koller D, Levinson DF.
Mol Psychiatry. 2014 Dec;19(12):1267-74.
Transcriptomic analysis of Staphylococcus aureus using microarray and advanced next-generation RNA-seq technologies.
Lei T, Becker A, Ji Y.
Methods Mol Biol. 2014;1085:213-29.
Identification of a new target of miR-16, Vacuolar Protein Sorting 4a.
Adhikari N, Guan W, Capaldo B, Mackey AJ, Carlson M, Ramakrishnan S, Walek D, Gupta M, Mitchell A, Eckman P, John R, Ashley E, Barton PJ, Hall JL.
PLoS One. 2014 Jul 17;9(7):e101509.
Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1.
Adhikari N, Billaud M, Carlson M, Lake SP, Montaniel KR, Staggs R, Guan W, Walek D, Desir S, Isakson BE, Barocas VH, Hall JL.
Mol Cell Biochem. 2014 Jan;385(1-2):225-38.
Fed state prior to hemorrhagic shock and polytrauma in a porcine model results in altered liver transcriptomic response.
Determan C Jr, Anderson R, Becker A, Witowski N, Lusczek E, Mulier K, Beilman GJ.
PLoS One. 2014 Jun 17;9(6):e100088.
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA.
Nat Genet. 2013 Jun;45(6):613-20.
Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.
Robien K, Butler LM, Wang R, Beckman KB, Walek D, Koh WP, Yuan JM.
Br J Nutr. 2013 Feb 14;109(3):493-502.