Illumina MethylationEPIC Microarrays


Overview

The Illumina Infinium MethylationEPIC microarray is based on the Illumina Infinium genotyping platform and queries individual CpG sites across the human genome by measuring the C/T ratio following bisulfite conversion of DNA, thereby permitting the % methylation of each CpG site to be ascertained. This 850,000-feature array is an update to Illumina’s popular HumanMethylation450 methylation platform with the addition of Enhanced and Promoter Informed Content. This beadchip contains > 90% of the original Infinium Methylation450 BeadChip content plus an additional 350,000 CpGs in enhancer regions. Content on the BeadChip was selected by a global consortium of epigenomics experts and covers:

  • CpG islands
  • RefSeq genes
  • ENCODE open chromatin
  • ENCODE transcription factor binding sites
  • FANTOM5 enhancers

Click here for more details on the MethylationEPIC array’s design and performance. Below are links to publications describing the validation of the platform.

Certification


As Certified Service Providers for the Illumina Infinium arrays, we undergo annual certification to guarantee our clients receive reliable methylation values for each CpG locus using the most up-to-date workflows. 

Questions?


Contact Jerry Daniel: genotype@umn.edu

Pricing

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UMN Rates

ServiceSavings TierSpeed TierPriority Tier
Illumina Infinium Human MethylationEPIC.$229.90$272.55$330.16
Turnaround time.26 to 60 days15 to 26 days8 to 12 days
Illumina Infinium Mouse Methylation.$270.86$315.18$374.45
Turnaround time.26 to 60 days15 to 26 days8 to 12 days


Notes
1. Pricing includes all costs for bisulfite conversion, EPIC or Mouse Methylation arrays, reagents, processing, and primary analysis. Service must be purchased in multiples of 8 (EPIC) or 12 (Mouse) samples. There is an additional charge for shipping the arrays.         
2. Tiers: Turnaround time (TAT) is in business days. Availability for the Priority Tier is limited; contact genotype@umn.edu to see if this is a current option.                    

External Rates

ServiceSavings TierSpeed TierPriority Tier
Illumina Infinium Human MethylationEPIC.$293.26$340.90$404.78
Turnaround time.26 to 60 days15 to 26 days8 to 12 days
Illumina Infinium Mouse Methylation.$345.53$395.09$460.79
Turnaround time.26 to 60 days15 to 26 days8 to 12 days

Notes
1. Pricing includes all costs for bisulfite conversion, EPIC or Mouse Methylation arrays, reagents, processing, and primary analysis. Service must be purchased in multiples of 8 (EPIC) or 12 (Mouse) samples. There is an additional charge for shipping the arrays.         
2. Tiers: Turnaround time (TAT) is in business days. Availability for the Priority Tier is limited; contact genotype@umn.edu to see if this is a current option.                     

Guidelines

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Submission

How to Order


Complete the DNA Plate Submission Form for submitting samples and email to genotype@umn.edu.

Researchers should submit a minimum of 500 ng of DNA per sample at 25 ng/ul in a 96-well plate in a COLUMN-WISE fashion RANDOMIZING samples and keep two unique blank wells. Please review our MethylationEPIC Sample Submission Form Guidelines.

Samples can be dropped off at one of our campus locations:

1-210 Cancer & Cardiovascular Research Building (Minneapolis campus)
20 Snyder Hall (St. Paul campus)

If shipping samples, the following address should be used:

Please send the tracking information to genotype@umn.edu.

UMN Genomics Center
ATTN: Nick Jones/ Jerry Daniel
3510 Hopkins Place N.
Building 4 Suite W402
Oakdale, MN 55128
612-625-7736

Deliverables

Client is emailed the GenomeStudio project file as well as data in Excel.