NanoString GeoMx Digital Spatial Profiler

NanoString’s GeoMx Digital Spatial Profiler (DSP) combines standard immunofluorescence techniques with digital optical barcoding technology to perform highly multiplexed, spatially resolved profiling experiments. In a single reaction, the DSP technology performs whole slide imaging with up to four fluorescent stains to capture tissue morphology and select regions of interest for high-plex profiling. The DSP chemistry enables spatially resolved high-plex profiling of RNA and protein targets on just two serial sample sections, with non-destructive tissue processing.

• Minimum sample: protein or RNA analysis from formalin-fixed paraffin-embedded (FFPE) or fresh-frozen section.
• Morphological context: whole-slide four-color imaging to guide profiling.
• Digital quantitation: up to 6 logs (base 10) dynamic range.
• Preserve precious samples with non-destructive processing.

Explore the UMN Spatialomics Initiative website to learn more about the GeoMx DSP and to compare technical details to other spatial platforms.

Questions

As the first school in the Big Ten to receive the DSP instrument and adopt this novel technology, the UMGC and UIC scientists use their technical experience to guide and inform researchers on the advantages and current limitations of the technology. Contact Dr. Fernanda Rodriguez at [email protected] with questions on the NanoString’s DSP platform or to schedule a consultation.